Six clinical actives— one formula.
The Pre’s psycho- and neuroactive system isn’t built on a single active. It rests on six actives with a clinical background that work in the shared language of skin and nervous system.
What does smart actually mean?
Smart here isn’t a marketing word. It means the actives don’t only work on the surface of the skin — they speak through the skin to the nervous system, too: through the peripheral nerve endings to the parasympathetic branch, the state of calm and recovery. This dual action is what sets a state cosmetic — a state, not a product — apart from ordinary skincare.
The formula is a well-functioning system because the six actives serve one purpose not separately but together: quieting and stabilising the skin–nervous-system connection. The J.S. Hamilton study was run with the Base Cream over four weeks — this clinical measurement examined the Base Cream formula.
TIMOOD™ — peptide platform.
What it does. TIMOOD™ is a trademarked peptide active developed to support skin–nervous-system communication. Through the nerve endings present in the skin it quiets the signals that carry the sense of stress, so the skin sends „fewer alarms" toward the limbic brain. The feeling is a calmer, more settled state of mind.
Where it’s present. TIMOOD™ is the first active of the Base Cream and Soul Foundation® shared platform. It’s in both formulas — in the Base Cream as an evening-and-morning skincare base, and in the Soul Foundation® it carries the same active in the daytime layer of the smart makeup.
IBR Chill™ — natural flavonoid.
What it does. IBR Chill™ is a natural flavonoid-based active (Daphne gnidium extract) documented to moderate the skin’s perceived tension response. Alongside softening the sense of redness it supports a general feeling of skin-calm — giving a measurable comfort direction especially for sensitive, reactive skin.
Where it’s present. IBR Chill™ is the platform’s second active, and the key to calm in the Base Cream formula. The Soul Foundation® references it too, as part of the shared, clinically tested neuroactive active platform.
Sepibliss — parasympathetic stabilisation.
What it does. Sepibliss is an active made of special fatty acids that supports the softening of the skin’s perceived tension response and helps the sense of sebum balance. Under stress the skin often produces oil reactively — Sepibliss quiets this reaction, so the skin barrier stays closer to a balanced state.
Where it’s present. Sepibliss is the Base Cream’s third active. The Soul Foundation® references the shared platform, but the Sepibliss concentration is tied primarily to the Base Cream formula — in the barrier-stabilising layer of the 28-day ritual.
Menthyl PCA — a sense of freshness.
What it does. Menthyl PCA is an active formed from menthol and pyrrolidone carboxylic acid that gives a discreet, gentle cooling sensation — not the classic menthol sting, but a quiet freshness that supports a parasympathetic body-sense. The skin receives a „you are here" signal, which anchors the opening moment of the ritual.
Where it’s present. Menthyl PCA works primarily as a morning base in the Base Cream, but it also appears in the daytime layer of the Soul Foundation® — tied to the freshness experienced in the smart makeup. Both products use it to give a „I wake up in my own skin" feeling.
Niacinamide — vitamin B3.
What it does. Niacinamide (vitamin B3) is one of the most widely documented barrier-supporting actives. It acts on the skin’s ceramide production, so hydration and barrier function stabilise; it also supports a sense of pigment balance and a more even-looking complexion. The platform’s „quiet team player".
Where it’s present. Niacinamide is present in both main products. In the Base Cream formula it’s one of the key actives of the 28-day barrier-stabilising layer; the same vitamin B3 supports the daytime comfort layer of the Soul Foundation®, behind the smart makeup.
Palmitoyl Tripeptide-8 — neuropeptide.
What it does. Palmitoyl Tripeptide-8 is a targeted cosmetic neuropeptide documented to moderate the skin’s sense of tension and to steer reactive skin in a comfort direction. A kind of inflammation modulator — it quiets the responses of micro-tension perceived in the skin, so the skin settles onto a „calmer base".
Where it’s present. Palmitoyl Tripeptide-8 is the Base Cream’s sixth active. The Soul Foundation® references the shared platform, but the clinically documented concentration is tied to the Base Cream formula — in the 28-day skin-state stabilising layer.
Six actives, one platform.
Together the actives form a system, not separate courses of treatment. The Base Cream and the Soul Foundation® use the same platform, in different ritual roles: the Base Cream is the 28-day evening-and-morning anchor, the Soul Foundation® the daytime comfort layer of the smart makeup. The J.S. Hamilton study was run with the Base Cream — the Soul Foundation® is the morning branch of the platform on the same scientific foundation.
Now you know the ingredients.
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Clinical background →